[3dem] Research Scientist to join the cryo-EM team in ALPX. DEADLINE IS APPROACHING!

Tue Nov 12 02:09:05 PST 2024

Dear EM enthusiasts,

Please find below details about a new open position for a Research 
Scientist to join the cryo-EM team in ALPX. *DEADLINE IS APPROACHING!*

Thank you and kind regards,
Erika

*Research Scientist in Cryo-Electron Microscopy at ALPX*

_Position description:_

ALPX is an EMBL Spin-off Company located in Grenoble, France 
(https://urldefense.com/v3/__http://alpx-services.com__;!!Mih3wA!HraCokgmc0akH8p_lUUD5XA3SjJ4WagZuB8fYRXfe_mpkiKjkIXd1v4xD0O5SE_IXwWizphLP0WxXCaNQDEdifDSgWw4$ ). We offer innovative research services based 
on the CrystalDirect technology for structural biology and 
small-molecule drug discovery to the pharmaceutical and biotech 
industries. Starting in 2025, we will also offer a rapid and agile 
Single Particle Analysis cryo-Electron Microscopy (SPA cryo-EM) full 
service, encompassing everything from cryo-EM sample preparation to 
structure determination.

We seek a highly motivated single-particle cryo-EM specialist to join 
the ALPX team.

The successful candidate will contribute to a range of exciting 
structural biology and drug discovery projects and participate in the 
development of our sample-to-solution cryo-EM service, with a particular 
focus on automating on-the-fly and offline data processing. 
Responsibilities include single-particle data acquisition and analysis, 
implementation and optimization of cryo-EM data storage, on-the-fly data 
processing, and high-quality structure elucidation and interpretation. 
The candidate will also assist in writing project proposals, working 
with various cryo-EM platforms, traveling for data collection, and 
preparing presentations on structural data for the project team and clients.

_Required knowledge, skills, and abilities:_

·        Ph.D. in chemistry, biology, physics, or a related field, with 
an excellent track record

·        Multiple cryo-EM map/structure depositions and peer-reviewed 
publications

·        Demonstrated extensive experience in hands-on TEM operation 
(Tecnai T12, Glacios, Titan Krios), data acquisition, image processing, 
model building

·        Strong expertise in a variety of cryo-EM and structural 
analysis software (i.e., Relion, CryoSPARC, EMAN, CCPEM, Chimera and COOT)

·        Experience in high-resolution structure determination by 
cryo-EM, including model building from scratch and structure refinement 
(Cccp4 and Phenix)

·        Scripting experience (Shell, Python)

·        Team player with the ability to work on several projects in 
parallel

·        Strong oral and written English communication and organisation 
skills

_Preferred knowledge, skills, and abilities:_

·        Experience in SPA cryo-EM on membrane proteins and epitopes mapping

·        Experience in Industry/CRO/CMO

·        Familiarity with HPC and Cloud Platforms

·        Experience in cryo-electron tomography (Cryo-ET) and 
sub-tomogram averaging

The position is permanent and immediately available. *Deadline for 
application: 17.11.2024.*

If you are enthusiastic about this position but find that your previous 
experience does not precisely match every requirement outlined in the 
job description, we still encourage you to apply. We are looking forward 
to hearing from you.

Please send your motivation letter, CV, and names of two referees to 
recruitment at alpx-services.com

linkedin.com/company/alpx-sas

-- 
*Erika Pellegrini*
Research scientist
pellegrini at alpx-services.com
https://urldefense.com/v3/__https://alpx-services.com__;!!Mih3wA!HraCokgmc0akH8p_lUUD5XA3SjJ4WagZuB8fYRXfe_mpkiKjkIXd1v4xD0O5SE_IXwWizphLP0WxXCaNQDEdifkzkjJl$ 

<https://urldefense.com/v3/__https://alpx-services.com__;!!Mih3wA!HraCokgmc0akH8p_lUUD5XA3SjJ4WagZuB8fYRXfe_mpkiKjkIXd1v4xD0O5SE_IXwWizphLP0WxXCaNQDEdifkzkjJl$ > 
<https://urldefense.com/v3/__https://www.linkedin.com/company/alpx-sas/posts/?feedView=all__;!!Mih3wA!HraCokgmc0akH8p_lUUD5XA3SjJ4WagZuB8fYRXfe_mpkiKjkIXd1v4xD0O5SE_IXwWizphLP0WxXCaNQDEdiW8t3TD0$ >

71 avenue des Martyrs
38000 Grenoble, France
Phone: +33476207967

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