[3dem] open position at Regeneron Pharmaceuticals

[Matthew Franklin]

Dear colleagues -

I would like to let you know about a job opening in my group at Regeneron Pharmaceuticals.  My group's primary focus is experimental single-particle cryoEM, but we are branching out into cryoET and computational structural biology, and are interested in talking to candidates from those fields as well.  We have our own microscopes (Krios/K3/Bioquantum and Glacios/Falcon 4/Selectris) and strong support from our biological colleagues and from top leadership at the company.  We publish regularly, and also contribute substantially to developing medicines that have helped many people across the world.

This position is intended for someone with a PhD and 0-5 years postdoctoral experience, or a BS/MS and 8-10 years of relevant experience.  The full job description is below.  If you're interested in applying, please go to https://urldefense.com/v3/__https://regeneron.wd1.myworkdayjobs.com/Careers/job/TARRYTOWN/Sr-Scientist---Structural-Biology_R37579__;!!Mih3wA!Fv1Rekh51_VQ2ZB4CByWQgU0T4OMEpZFpAKdgWzd2HwO3LZxLWL5cnQvmtE2V51f-IUfV9TAfGsvFQanw9YX5j2o8M6t07DX$ 

Thanks very much!
- Matt Franklin, Director of Structural Biology, Regeneron Pharmaceuticals



Full job description follows:

We are seeking a PhD-level scientist to join our growing structural biology group.  This position will be primarily focused on cryo-electron microscopy of molecules in Regeneron's drug development pipeline, including membrane proteins, large multi-protein assemblies, and antibody-target complexes.  Other possible projects may include cryo-electron tomography or computational structure prediction and analysis, depending on the successful candidate's skills.  This is a tremendous opportunity for an individual to contribute to projects of real medical impact.

The structure group's work involves many of the stages of a structural biology project, from protein characterization and complex purification, to grid preparation, cryoEM data collection, map refinement, structure determination, and structure analysis.  Earlier stages such as cloning, protein expression, and protein purification will be carried out by other groups at Regeneron, but we will still be involved, e.g. when special protein constructs are required for the structural studies.  We would like the candidate to have experience in these areas, as well as the ability to provide clear guidance to collaborators if the work is not done in our group.  However, we are also interested in candidates who have specialized in other structural techniques such as computational structural biology.

This position is intended to be cross-disciplinary, using cryoEM single-particle analysis, cryo-electron tomography, X-ray crystallography, computational structural biology, or a mix of these techniques, to produce the most useful results for a given project.  We recognize that no candidate will have all of the skills listed above.  In the group as a whole, we have a great deal of experience in these areas, so this position could be a tremendous learning opportunity for an individual who is flexible and creative, and willing to learn.

We have extensive resources for cryoEM structure determination in house, including a Titan Krios microscope with K3 BioQuantum, a Glacios microscope with Falcon 4 and Selectris energy filter, and a robust cloud computational environment for cryoEM data processing and in silico techniques (e.g. AlphaFold, Rosetta).  The successful candidate will be strongly encouraged to bring their own ideas and experience to help improve the quality of our research, and to continue innovating after they start here.

This position will be highly collaborative, interacting with scientists in all areas of Regeneron R&D and beyond.  The person hired for this job will need to understand complex research projects involving many different scientific areas, contribute in project meetings to shape the direction of the research, clearly communicate their structural results to an audience of non-structural biologists, and direct the course of their own work without extensive supervision.  Not all projects will require a high-resolution structure, and one of the major challenges of this work will be to plan out experiments that can be executed rapidly and deliver structural data quickly enough to remain relevant for the larger drug development effort.

This position is intended for an early-career structural biologist, perhaps someone with X-ray crystallographic training who wants to learn cryo-electron microscopy, or a cryoEM scientist who wants to expand into computational biology.  The candidate should have a PhD in structural biology, focusing on cryo-electron microscopy, X-ray crystallography, or computational biology.  Postdoctoral experience (<5 years) is also desirable, but not required.  Candidates with a BS/MS and 8-10 years of relevant experience are also encouraged to apply.

Since this position will be hands-on in the lab, a substantial amount of experience purifying and characterizing proteins is strongly preferred.  Direct experience with membrane proteins will be an advantage.  Candidates whose background is in other areas (e.g. computational biology, or cryoET of whole organisms) are welcome to apply if they want to expand their scientific skills.

The successful candidate must have a demonstrated track record of independent research including one or more first-author publications.

This position will involve work on many different projects simultaneously, so excellent record-keeping and time management skills are very important, as well as the ability to absorb new information rapidly.  The candidate must be able to work collaboratively with scientists from other fields of research, and be able to explain their results clearly and concisely to many different audiences, most of whom will have little or no experience in structural biology.



--
Matthew Franklin, Ph.D.
Director of Structural Biology
Regeneron Pharmaceuticals, Inc.
+1 914 847 7924








Regeneron - Internal

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