[3dem] postdoc position available in Peijun Zhang's group at eBIC, UK

[Peijun Zhang]

Postdoctoral Research Associate in eBIC - Androgen receptor with novel antagonists

Harwell, Oxfordshire

Salary £37,087 to £40,754 per annum (Discretionary range to £46,868).

Full time, fixed 1 year for the first instance (potentially to 3 years).



https://urldefense.com/v3/__https://vacancies.diamond.ac.uk/vacancy/postdoctoral-research-associate-androgen-receptor-with-novel-antagonists-540865.html__;!!Mih3wA!HzlfW63MsrG_Two5Bim-Z3ojDO35pacFZuL6wLEk0mrzujFaOSd0_A55A0tFd5y5cupNABbN1I0eAZthoRIunPX6W-nxbaSE$ 





A postdoc position is available in Professor Zhang's lab at the Electron Bio-Imaging Centre (eBIC), Diamond Light Source, UK. The post is funded by an NIH R21 award on "Structural and functional analysis of a novel class of androgen receptor antagonists".


Castration-resistant prostate cancer (CRPC) is currently incurable and is the second leading cause of cancer death in American men. Androgen-independent activation of the androgen receptor (AR) remains the major driving force leading to CRPC. Structural and functional analysis of a novel class of AR antagonists capable of inducing AR degradation in the nucleus may lead to new therapeutics for CRPC. The posts will take part in the collaborative team research to understand the underlying molecular mechanisms of the inhibition and degradation of nuclear AR by this class of antagonists using structural biology approaches.

We are seeking highly motivated scientist to conduct high-resolution structural analysis of AR in complexes with its antagonists. The post is based in eBIC, the UK national cryoEM facility, which provides scientists with state-of-the-art instruments and expertise in cryoEM. Currently eBIC houses four Titan Krios, a Talos Arctica, and a Glacios, two cryoFIB/SEM instruments (Scios and Aquilos), and a Leica cryoCLEM for correlative light and electron microscopy (https://urldefense.com/v3/__https://www.diamond.ac.uk/Instruments/Biological-Cryo-Imaging/eBIC.html__;!!Mih3wA!HzlfW63MsrG_Two5Bim-Z3ojDO35pacFZuL6wLEk0mrzujFaOSd0_A55A0tFd5y5cupNABbN1I0eAZthoRIunPX6WxiVRkmR$ ).



You should have a PhD degree in structural biology or equivalent and have a demonstrated record of accomplishment in conducting high quality original research. Knowledge and research experience in structural biology, including protein biochemistry and single particle cryoEM, are essential.



Applicants are required to outline their suitability for this role via the online application process and should include a CV, summary of their accomplishment and research interests, and publication list.

The initial closing date for applications is 12th November 2023, however applications will be reviewed and interviewed on an ongoing basis until this vacancy is filled.



For further information about this role please contact Peijun Zhang (peijun.zhang at diamond.ac.uk<mailto:peijun.zhang at diamond.ac.uk>).



Other information

Diamond offers an exceptional benefits package to ensure an excellent work/life balance including 25 days' annual leave, 13 days statutory and company holidays, flexible working hours, an onsite nursery, an excellent pension scheme, and social and sporting activities.

  *   Company benefits<https://urldefense.com/v3/__http://www.diamond.ac.uk/Careers/Company-Benefits.html__;!!Mih3wA!HzlfW63MsrG_Two5Bim-Z3ojDO35pacFZuL6wLEk0mrzujFaOSd0_A55A0tFd5y5cupNABbN1I0eAZthoRIunPX6W3Mf6rIt$ >
  *   Life at diamond<https://urldefense.com/v3/__http://www.diamond.ac.uk/Careers/Applicant-Information/LocalArea.html__;!!Mih3wA!HzlfW63MsrG_Two5Bim-Z3ojDO35pacFZuL6wLEk0mrzujFaOSd0_A55A0tFd5y5cupNABbN1I0eAZthoRIunPX6W1c05Xfr$ >


Peijun Zhang
Professor
Division of Structural Biology
Wellcome Trust Centre for Human Genetics
University of Oxford
Roosevelt Drive Oxford OX3 7BN, UK
Peijun.zhang at strubi.ox.ac.uk<mailto:Peijun.zhang at strubi.ox.ac.uk>
https://urldefense.com/v3/__https://www.ndm.ox.ac.uk/team/peijun-zhang/view__;!!Mih3wA!HzlfW63MsrG_Two5Bim-Z3ojDO35pacFZuL6wLEk0mrzujFaOSd0_A55A0tFd5y5cupNABbN1I0eAZthoRIunPX6W9GIQoXd$ 

Director
Electron Bio-Imaging Centre
Diamond Light Source
https://urldefense.com/v3/__https://www.diamond.ac.uk/Instruments/Biological-Cryo-Imaging/eBIC.html__;!!Mih3wA!HzlfW63MsrG_Two5Bim-Z3ojDO35pacFZuL6wLEk0mrzujFaOSd0_A55A0tFd5y5cupNABbN1I0eAZthoRIunPX6WxiVRkmR$ 

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