[3dem] Postdoctoral research associate position at King's College London

[Joseph Atherton]

Applications are invited for a postdoctoral research associate to be based in the Department of Basic and Clinical Neuroscience and the Randall Centre for Cell and Molecular Biophysics at King’s College London. The post is funded by the UK Medical Research Council for 3 years and will investigate the role of defective endoplasmic reticulum (ER)-mitochondria signalling in dementia and amyotrophic lateral sclerosis (ALS).

ER-mitochondria signaling and its role in dementia/ALS are highly topical areas of research and the grant holders have made major contributions to these fields. The successful applicant will join a multi-disciplinary group that seeks to understand the mechanisms by which ER-mitochondria signalling is perturbed in dementia/ALS and how correcting damaged ER-mitochondria signalling might be therapeutic for these major diseases.

The post will focus on gaining high-resolution structural information on ER-mitochondria tethers using cryo-electron microscopy (cryo-EM) methods. Experience in structural biology methods and especially cryo-EM, and protein purification methods will be valuable. The successful applicant will have access to state-of-the-art facilities in both King’s College, the King’s College Dementia Research Institute and the Crick Institute. KCL have access to a Titan Krios with a K3 direct electron detector located at the Crick Institute and also have on-site cryo-EM sample preparation, screening and data collection facilities, including a JEOL CryoARM200 equipped with a K3 direct electron detector (to be installed in July 2023).

You can apply and find more information here;
https://urldefense.com/v3/__https://www.kcl.ac.uk/jobs/068946-research-associate-structural-studies-of-er-mitochondria-tethers__;!!Mih3wA!CWtDtCe5umdCOJF7IislvODtydKAzoFoKQ6m9R9sUqpsWsabx-sqD59JqKs7rBArKZ-pyWoC2loMJld9X_mS9_RI0uycAb8$ 

You can also contact Joe Atherton (leading the structural work, joseph.atherton at kcl.ac.uk<mailto:joseph.atherton at kcl.ac.uk>), or Chris Miller (leading the overall project, chris.miller at kcl.ac.uk<mailto:chris.miller at kcl.ac.uk>) for more information.

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