[3dem] Postdoc and Scientist Positions in Structural Virology, U Washington

[Kelly Lee]


Postdoctoral Fellow and Research Scientist positions in structural biology and biophysics of infectious disease

Come work with us in the Lee Lab, University of Washington, Seattle.

Our lab applies cryo-electron tomography, single particle cryo-EM, and biophysical approaches including structural mass spectrometry (H/D-exchange MS) to investigate the machinery and mechanisms of infection by human viruses. We are fascinated by the dynamic aspects of enveloped virus entry and membrane fusion. Another major focus is to understand the structural and dynamic origins of antigenic and immunogenic variation in rapidly evolving viruses such as HIV, influenza, and other RNA viruses.

To learn more about our work, see for example:

Visualization of Conformational Changes and Membrane Remodeling Leading to Genome Delivery by Viral Class-II Fusion Machinery.
Mangala Prasad V, Blijleven JS, Smit JM, Lee KK. 
Nature Communications. 2022 13:4722 doi: 10.1038/s41467-022-32431-9
 
Structural Dynamics Reveal Isolate-specific Differences at Neutralization Epitopes on HIV Env
Hodge EA, Naika GS, Kephart SM, Nguyen A, Zhu R, Benhaim MA, Guo W, Moore JP, Hu S-L, Sanders RW, Lee KK
iScience. 2022 Jun 17 25:104449

Cryo-ET of Env on Intact HIV Virions Reveals Structural Variation and Positioning on the Gag Lattice
Mangala Prasad V, Leaman D, Lovendahl K, Croft JT, Hodge EA, Benhaim MA, Zwick MB, Lee KK
Cell. 2022 Feb 17 185:1-13

Structural Monitoring of a Transient Intermediate in the Hemagglutinin Fusion Machinery on Influenza Virions
Benhaim MA, Mangala Prasad V, Garcia NK, Guttman M, Lee KK
Science Advances. 2020 Apr 29;6(18):eaaz8822

For more information contact Kelly Lee at kklee at uw.edu (https://urldefense.com/v3/__https://www.lee-lab-fusion.org__;!!Mih3wA!FYFuODjuptv_06TFUyY13RpsLazZb7L8aGLgOa0EM-WGSMMP4Uj3VDCQgfIqVfvbiqBYSoviZHDQUagq$  ) 

Responsibilities
Employ cryo-electron tomography approaches, single particle cryo-EM, or complementary quantitative biophysical methods such as mass spectrometry, fluorescence microscopy and computational modeling to analyze protein-mediated membrane fusion machinery and interactions with host factors such as receptors, membranes, and antibodies. Opportunities for training in additional techniques and collaborations in related virology and immunology areas are available.

Qualifications
The successful candidate must have a Ph.D. or equivalent degree. Experience in cryo-EM/ET with single-particle or subtomogram averaging is desirable, though candidates with expertise in biophysics, structural biology, or computational modeling methods are also encouraged to apply. We are a highly collaborative group, and working well with and appreciating our colleagues is a skill we value.

________________________________

Kelly Lee, Ph.D.

Professor
Department of Medicinal Chemistry
University of Washington

kklee at uw.edu
https://urldefense.com/v3/__https://www.lee-lab-fusion.org__;!!Mih3wA!FYFuODjuptv_06TFUyY13RpsLazZb7L8aGLgOa0EM-WGSMMP4Uj3VDCQgfIqVfvbiqBYSoviZHDQUagq$  

-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://mail.ncmir.ucsd.edu/pipermail/3dem/attachments/20220913/ce971fed/attachment.html>