[3dem] POSTDOCTORAL POSITIONS - MINOR LAB @ UCSF in Structural mechanisms of ion channel assembly and design of toxin sponge proteins

Minor, Daniel Daniel.Minor at ucsf.edu
Mon Oct 10 18:38:40 PDT 2022 


Postdoctoral Positions in:

1)   Structural biology of ion channel assembly mechanisms

2)   Structural studies and protein design of toxin sponge proteins

MINOR LAB UCSF - Cardiovascular Research Institute

Multiple postdoctoral positions are available immediately for highly motivated individuals with strong backgrounds in biophysics, biochemistry, structural biology, or computational methods, and an interest in structural biology of ion channel assembly mechanisms or structural studies and protein design of toxin sponge proteins in the lab of Prof. Dan Minor at the University of California, San Francisco (UCSF). The Minor Lab merges structural, biochemical, chemical biology, genetic, and electrophysiological methods to dissect mechanisms of complex protein machines involved in electrical signaling and to uncover mechanisms of toxin resistance in poison organisms.

1)    Structural biology of ion channel assembly
Projects focus on cryo-EM and other approaches to study the structural principles of ion channel assembly and interactions with chaperones. Candidates should have (or expect) an Ph.D. or M.D. and should have demonstrated achievements in protein biochemistry or biophysics, X-ray crystallography, cryo‑electronmicroscopy, or electrophysiology. Computational skills are also highly desired.
Ongoing work is represented by: 
Arrigoni, C., Lolicato, M., Shaya, D., Rohaim, A., Findeisen, F., Fong, L.-K., Colleran, C.M., Dominik, P., Kim, S.S., Schuermann, J., DeGrado, W.F., Grabe, M., Kossiakoff, A.A., and Minor, D.L., Jr.
'Quaternary structure independent folding of voltage-gated ion channel pore domain subunits' 

Nature Structural and Molecular Biology 29 537-548 (2022)  https://wsww.nature.com/articles/s41594-022-00775-x <https://www.nature.com/articles/s41594-022-00775-x> 

Chen, Z., Mondal, A., Abderemane-Ali, F., Montano, J., Zaro, B., and Minor, D.L., Jr.,
’EMC holdase:CaV1.2/CaVβ3 complex and CaV1.2 channel structures reveal CaV assembly and drug binding mechanisms’ bioRxiv https://www.biorxiv.org/content/10.1101/2022.10.03.510667v1 <https://www.biorxiv.org/content/10.1101/2022.10.03.510667v1>
2)    Structural studies and protein design of toxin sponge proteins
This project focuses on using structural biology, protein engineering, computational design, and molecular evolution to characterize and develop new toxin sponge proteins. Candidates should have (or expect) an Ph.D. or M.D. and should have demonstrated achievements in protein structure analysis, protein biophysics, computational methods, or selection methods. Computational skills are highly desired.
Ongoing work is represented by: 
Yen, T.-J., Lolicato, M., Thomas-Tran, R., Du Bois, J., and Minor, D.L., Jr., 

'Structure of the Saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins' Science Advances 5, eaax2650 (2019) aax2650 <https://www.science.org/doi/10.1126/sciadv.aax2650>
Chen, Z., Zakrzewska, S., Hajare, H., Alvarez-Bullya, A.,  Abderemane-Ali, F., Bogan, M., Ramirez, D., O’Connell, L.A., Du Bois, J., and Minor, D.L., Jr.
'Definition of a saxitoxin (STX) binding code enables discovery and characterization of the Anuran saxiphilin family’ Proceedings of the National Academy of Sciences, USA (in press) and bioRxiv https://www.biorxiv.org/content/10.1101/2022.06.09.495489v1 <https://www.biorxiv.org/content/10.1101/2022.06.09.495489v1>
More information is available at the lab website http://www.cvri.ucsf.edu/~dminor/ <http://www.cvri.ucsf.edu/~dminor/>
Fellows will benefit from both the outstanding lab environment and the highly collaborative UCSF community.
TO APPLY: Interested individuals should send a current CV to Prof. Daniel Minor at daniel.minor at ucsf.edu <mailto:daniel.minor at ucsf.edu>
 @ElectrosomeUCSF


Dan Minor, Ph.D.
Professor
Cardiovascular Research Institute
Departments of Biochemistry & Biophysics,
and Cellular & Molecular Pharmacology
California Institute for Quantitative Biomedical Research
Kavli Institute for Fundamental Neuroscience
University of California, San Francisco


FEDEX/UPS address:

Cardiovascular Research Institute
Box 3122
University of California San Francisco
555 Mission Bay Blvd. South. Rm 452Z
San Francisco, CA 94158-9001

Email: daniel.minor at ucsf.edu <mailto:daniel.minor at ucsf.edu>
Phone: 415-514-2551
Fax: 415-476-8173
Web: http://www.cvri.ucsf.edu/~dminor <http://www.cvri.ucsf.edu/~dminor>
Twitter:http://twitter.com/ElectrosomeUCSF <http://twitter.com/ElectrosomeUCSF>
Dan Minor, Ph.D.
Professor
Cardiovascular Research Institute
Departments of Biochemistry & Biophysics,
and Cellular & Molecular Pharmacology
California Institute for Quantitative Biomedical Research
Kavli Institute for Fundamental Neuroscience
University of California, San Francisco


FEDEX/UPS address:

Cardiovascular Research Institute
Box 3122
University of California San Francisco
555 Mission Bay Blvd. South. Rm 452Z
San Francisco, CA 94158-9001

Email: daniel.minor at ucsf.edu <mailto:daniel.minor at ucsf.edu>
Phone: 415-514-2551
Fax: 415-476-8173
Web: http://www.cvri.ucsf.edu/~dminor <http://www.cvri.ucsf.edu/~dminor>
Twitter:http://twitter.com/ElectrosomeUCSF <http://twitter.com/ElectrosomeUCSF>
Dan Minor, Ph.D.
Professor
Cardiovascular Research Institute
Departments of Biochemistry & Biophysics,
and Cellular & Molecular Pharmacology
California Institute for Quantitative Biomedical Research
Kavli Institute for Fundamental Neuroscience
University of California, San Francisco


FEDEX/UPS address:

Cardiovascular Research Institute
Box 3122
University of California San Francisco
555 Mission Bay Blvd. South. Rm 452Z
San Francisco, CA 94158-9001

Email: daniel.minor at ucsf.edu
Phone: 415-514-2551
Fax: 415-476-8173
Web: http://www.cvri.ucsf.edu/~dminor
Twitter:http://twitter.com/ElectrosomeUCSF



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