[3dem] Postdoc position for Amyloids as Substrate of Biological Functions by cryoEM in HKU

[sunnyyi1]

Postdoc position for Amyloids as Substrate of Biological Functions by cryoEM in HKU

Institution: School of Biomedical Sciences (SBMS), The University of Hong Kong (HKU)

Research lead: Ruben Hervas Ph.D.
Email address: ruhm at hku.hk<mailto:ruhm at hku.hk>

Summary of Role: A 3-years postdoctoral position is available in Dr. Ruben Hervas Team within the SBMS-HKU. The Post-doc will be involved in the structure determination of amyloids by cryo- electron microscopy (cryo-EM) as part of a research programme focused on Amyloids as Substrate of Biological Functions. The postholder will be responsible for sample preparation from human and animal tissue, structure determination by cryo-EM and subsequent structural and biochemical analysis of biologically active amyloids involved in memory persistence and animal development. The successful candidate will be an integral member of a multidisciplinary project team, will interact closely with biologists and computational biologists, and will have access to HKU state- of-the art cryo-EM facility, which includes an in-house Glacios and a Titan KRIOS as well as to the Centre for PanorOmic Sciences.

Key Requirements: The successful candidate must have must have a PhD (or equivalent) in a biological or physical science, with experience in cryo-EM specimen preparation and data processing. Experience in single particle cryo-EM is essential for this post. Experience in molecular biology, protein expression and protein purification will be an advantage.

Interested candidates should email CV and names of 2-3 references to ruhm at hku.hk<mailto:ruhm at hku.hk>.

Selected publications

Hervas R, Rau MJ, Park Y, Zhang W, Murzin AG, Fitzpatrick JAJ, Scheres SHW, Si K. Cryo EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila. Science. 367(6483):1230-1234. doi: 10.1126/science.aba3526 (2020)

Nil Z, Hervas R, Gerbich T, Leal P, Yu Z, Saraf A, Sardiu M, Lange JJ, Yi K, Unruh J, Slaughter B, Si K. Amyloid- like assembly activates a phosphatase in the developing Drosophila embryo. Cell. 179(3):801. doi: 10.1016/j.cell.2019.09.033. (2019)

Hervas R*, Li L*, Majumdar A, Fernández-Ramírez MDC, Unruh JR, Slaughter BD, Galera- Prat A, Santana E, Suzuki M, Nagai Y, Bruix M, Casas-Tintó S, Menéndez M, Laurents DV, Si K, Carrión-Vázquez M. Molecular basis of Orb2 amyloidogenesis and Blockade of memory consolidation. PLOS Biol. 14(1):e1002361. doi: 10.1371/journal.pbio.1002361. (2016)
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