[3dem] Postdoctoral position @ OSU

[krishna ch]

Dear All,

Applications are invited for a joint postdoctoral scientist position in the laboratories of Dr. Sarah Heissler and Dr. Krishna Chinthalapudi at the Ohio State University. The research project focuses on understanding the role of myosin motors and other cytoskeletal proteins in health and disease. We combine state-of-the-art structural biology approaches including X-ray crystallography and cryo-EM with biochemical, biophysical and cell biological methods to investigate how protein structure is related to its function. Our laboratories are equipped with state-of-the-art instrumentation for the proposed studies and have generous access to a Titan Krios G3i Cryo-TEM equipped with a bioquantum imaging filter and a K3 direct electron detector, imaging phase plates, STEM/TEM tomography, and an image spherical aberration corrector. In addition, our labs have access to a Glacios with a falcon III detector and Ceta-D camera for MicroED analysis at the world-class Center for Electron Microscopy and Analysis (CEMAS) at the Ohio State University.

Selected examples of our work include:

Heissler SM, Arora AS, Billington N, Sellers JR, Chinthalapudi K. Cryo-EM structure of the autoinhibited state of myosin-2. Sci Adv. 2021 Dec 24;7(52):eabk3273. doi: 10.1126/sciadv.abk3273.

Chinthalapudi K, Heissler SM, Preller M, Sellers JR, Manstein DJ. Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C. Elife. 2017 Dec 19;6:e32742. doi: 10.7554/eLife.32742.

Candidates must have (or will be shortly awarded) a Ph.D. degree and strong practical experience in biochemistry and structural biology. Experiences with molecular biology techniques, protein expression and purification, cell biology and/or high-resolution imaging are desirable.

 For more information, please contact us and/or visit our lab websites.

https://urldefense.proofpoint.com/v2/url?u=https-3A__medicine.osu.edu_find-2Dfaculty_non-2Dclinical_physiology-2Dand-2Dcell-2Dbiology_sarah-2Dheissler&d=DwIFAg&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=1iCeyu1WHTxl13NT4_uStpvIwCU_BagPCnNx6DK4Il3UlRYmh5VKCeZYMUFLieD7&s=mHCtzPzSOYY4f3cecou8Tksc7JkgWsPxkGg4VT_uX1U&e=  <https://urldefense.proofpoint.com/v2/url?u=https-3A__medicine.osu.edu_find-2Dfaculty_non-2Dclinical_physiology-2Dand-2Dcell-2Dbiology_sarah-2Dheissler&d=DwIFAg&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=1iCeyu1WHTxl13NT4_uStpvIwCU_BagPCnNx6DK4Il3UlRYmh5VKCeZYMUFLieD7&s=mHCtzPzSOYY4f3cecou8Tksc7JkgWsPxkGg4VT_uX1U&e= >
https://urldefense.proofpoint.com/v2/url?u=https-3A__medicine.osu.edu_find-2Dfaculty_non-2Dclinical_physiology-2Dand-2Dcell-2Dbiology_krishna-2Dchinthalapudi&d=DwIFAg&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=1iCeyu1WHTxl13NT4_uStpvIwCU_BagPCnNx6DK4Il3UlRYmh5VKCeZYMUFLieD7&s=enLsYpS8lF_iFcO5jg_hGK8j2i_C2bsZMs9fV0MmSWk&e=  <https://urldefense.proofpoint.com/v2/url?u=https-3A__medicine.osu.edu_find-2Dfaculty_non-2Dclinical_physiology-2Dand-2Dcell-2Dbiology_krishna-2Dchinthalapudi&d=DwIFAg&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=1iCeyu1WHTxl13NT4_uStpvIwCU_BagPCnNx6DK4Il3UlRYmh5VKCeZYMUFLieD7&s=enLsYpS8lF_iFcO5jg_hGK8j2i_C2bsZMs9fV0MmSWk&e= >
 

To be considered for this position, please email your curriculum vitae, a short cover letter with research experience and interests and contact information for three references to Sarah Heissler (sarah.heissler at osumc.edu <mailto:sarah.heissler at osumc.edu>) and Krishna Chinthalapudi (krishna.chinthalapudi at osumc.edu <mailto:krishna.chinthalapudi at osumc.edu>).

 

Thank you,

Sarah & Krishna
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://mail.ncmir.ucsd.edu/pipermail/3dem/attachments/20220114/54425c17/attachment.html>