[3dem] Postdoctoral position in Structural Virology at the Institut Pasteur

[Pablo Guardado Calvo]

*A two-year postdoctoral position is available in the group of Structural
Biology of Infectious Diseases (SBID) at the Institut Pasteur (Paris,
France)*

SBID is a new lab at the Institut Pasteur headed by Pablo Guardado-Calvo.
In the SBID we investigate the molecular mechanism of poxvirus entry into
target cells. We combine structural biology, biophysics and virology
approaches to characterise protein complexes. We aim to use the resulting
information to develop vaccines and therapies. For more information, you
can check our previous work done with bunyaviruses and flaviviruses (PMIDs:
32937107, 29097548, 27783711, 25581790).

We are looking for a person with excellent track record and motivation to
pursue a career in structural virology. The postdoctoral fellow will be in
charge of characterising large protein complexes using cryo-electron
tomography or SPA and of setting up functional assays to characterise their
activity in vitro. The postdoc will work in close collaboration with a
research engineer focused on related projects. The project will involve
protein and virus production, functional characterisation of ligands using
neutralisation and fusion assays and structural studies using cryo-electron
microscopy and crystallography. The group is hosted in friendly and dynamic
environment with extensive opportunities to learn new techniques and
establish collaborations. We have fully equipped P1 and P2 labs and the
Institut Pasteur is equipped with start-of-the-art microscopes, including
two 200 kV Glacios and a 300 kV Titan Krios equipped with a Falcon 4
detector and an energy filter. The synchrotron Soleil is less than 1 hour
from the Institut and we have fluid access to the crystallography and
biophysics platforms, which are excellently equipped.

Required qualifications
• A PhD in structural biology, biochemistry, biophysics or virology.
• Documented experience in at least one of the following techniques:
structural biology (cryo-electron microscopy), virology (manipulation of
poxviruses would be particularly appreciated, neutralisation assays) or
biophysical techniques (viral fusion assays).
• Good interpersonal skills

The application should contain
1. A letter of motivation (1 page) with a short description of your
research interests.
2. A CV, including a list of relevant skills, experiences and a full
publication list.
3. Names and e-mail addresses of 2-3 reference persons, indicating their
professional relation to you.

The starting date is negotiable. Ideally around March 2023, no later than
September.

Informal inquiries and application should be sent to Pablo Guardado-Calvo (
guardado at pasteur.fr)
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