[3dem] POSTDOCTORAL POSITION, CRYO-ELECTRON MICROSCOPY, MINOR LAB UCSF

[Minor, Daniel L]

UC San Francisco – Postdoctoral Position Opening
Ion Channel Structural and Chemical Biology

MINOR LAB UCSF - Cardiovascular Research Institute, Departments of
Biochemistry and Biophysics, & Cellular and Molecular Pharmacology

A Postdoctoral position is available immediately for highly motivated
individuals with a strong interest in studies of ion channels in the lab of
Prof. Dan Minor at the University of California, San Francisco
(UCSF).

The Minor Lab merges structural, biochemical, chemical
biology, genetic, and electrophysiological methods to dissect
mechanisms of complex protein machines involved in electrical signaling.
Projects focus on biochemical, electrophysiological, and cell based
approaches to studying ion channel function, the development of new
chemical biology tools to manipulate channel activity, studies of ion
channel lipid interactions, and on determining the structures of ion
channel complexes by both crystallographic and single particle
cryo-electron microscopy (cryo-EM) approaches. 

The fellow will benefit from both the outstanding lab environment and the highly
collaborative UCSF community. As part of the UCSF Macromolecular
Structure Group, the lab uses an extensive set of crystallographic and
cryo-EM resources, including: two R-axis IV systems, regular access to synchrotron beamline 8.3.1
at the nearby Advanced Light Source (ALS) in Berkeley, and on campus state-of-the-art Talos
Arctica and Titan Krios cryo-EMs using the latest generation of K2 Summit direct electron
detectors.

Ongoing projects focus on mechanisms of voltage-gated, thermosensitive, and mechanosensitive
channels and efforts develop new agents to control and image ion channels involved in pain
represented by:

Arrigoni, C., Rohaim, A., Shaya, D., Findeisen ,F., Stein, R.A. Nurva, S.R., Mishra, S.,
Mchaourab, H.S., and Minor, D.L., Jr., ‘Unfolding of a temperature-sensitive domain controls
voltage-gated channel activation’ Cell 164 922-936 (2016)

Lolicato, M., Arrigoni, C., Mori, T., Sekioka, Y., Bryant, C., Clark, K.A., Minor, D.L., Jr.
’K2P2.1(TREK-1):activator complexes reveal a cryptic selectivity filter binding site’
Nature 547 364-368 (2017)

 Lolicato, M., Natale, A., Abderemane-Ali, F., Crottès, D. Capponi, S., Duman, R., Wagner, A., Rosenberg, J.M., Grabe. M., and Minor, D.L., Jr. ’K2P2.1 channel C‑type gating involves asymmetric selectivity filter order-disorder transitions’ Science Advances 6 eabc9174 (2020)

More information is available at the lab website http://www.cvri.ucsf.edu/~dminor/

Candidates should have (or expect) an Ph.D. or M.D. and should have experience in protein
biochemistry, cell biology, electrophysiology, or structure determination by crystallographic or
cryo-electronmicroscopy methods.

TO APPLY:
Interested individuals should send a current CV to Prof. Daniel Minor at daniel.minor at ucsf.edu


Dan Minor, Ph.D.
Professor
Cardiovascular Research Institute
Departments of Biochemistry & Biophysics,
and Cellular & Molecular Pharmacology
California Institute for Quantitative Biomedical Research
Kavli Institute for Fundamental Neuroscience
University of California, San Francisco


FEDEX/UPS address:

Cardiovascular Research Institute
Box 3122
University of California San Francisco
555 Mission Bay Blvd. South. Rm 452Z
San Francisco, CA 94158-9001

Email: daniel.minor at ucsf.edu
Phone: 415-514-2551
Fax: 415-476-8173
Web: http://www.cvri.ucsf.edu/~dminor
Twitter:http://twitter.com/ElectrosomeUCSF



-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://mail.ncmir.ucsd.edu/pipermail/3dem/attachments/20210707/8b274001/attachment.html>
-------------- next part --------------
A non-text attachment was scrubbed...
Name: smime.p7s
Type: application/pkcs7-signature
Size: 1382 bytes
Desc: not available
URL: <http://mail.ncmir.ucsd.edu/pipermail/3dem/attachments/20210707/8b274001/attachment.p7s>