[3dem] Postdoctoral position in CryoEM Studies of Virus/Host Interactions (Phoebe Stewart)

[Phoebe Stewart]

The Stewart laboratory at Case Western Reserve University (CWRU) has an
opening for a talented postdoctoral fellow with experience in structural
biology. The project includes determining cryoEM structures of adenovirus
in complex with various host immune factors with the goal of enhancing our
understanding of adenovirus neutralization. The position is for two years
and is renewable for an additional year.

Adenovirus (Ad) vectors are being developed for use as oncolytic viruses,
as well as for vaccine and gene therapy applications. Despite many
advantages of Ad vectors as potential therapeutics, the potent systemic
inflammation that is triggered by intravascular administration of Ad
remains a serious barrier to clinical applications. The molecular
mechanisms underlying the exacerbation of systemic inflammation are poorly
understood. The proposed structural studies will provide new mechanistic
insights into fundamental functions of innate and adaptive immunity and
host anti-viral defense. This is an ongoing collaborative project with the
Shayakhmetov group at Emory University (see e.g. Atasheva et al., Science
Translational Medicine, 2020)

The Stewart lab has excellent access to transmission cryo-electron
microscopes, including a Titan Krios equipped with a BioQuantum K3
detector, at the CWRU cryo-electron microscopy core (see
https://urldefense.proofpoint.com/v2/url?u=https-3A__case.edu_medicine_ccmsb_&d=DwIBaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=Ce4X34Pcd_AWekIr5st0x36l1Q3Avf8_oBVFTrlBErVz2iMTT2grxZwoaawMpN63&s=3deCemk_gW0rrTQK4wUVxYAV6CSnwPDk4Akn0SFmhpU&e= ). In addition, the lab utilizes the High
Performance Computing Cluster at CWRU.

Candidates for this position must have a PhD degree in a biological
science, experience in structural biology, experience manipulating protein
or virus samples, and have good writing and communication skills.
Experience in cryoEM is preferred, but not required.

Cleveland, Ohio offers a vibrant and affordable place to live with access
to a variety of cultural and outdoor activities. Interested applicants
should email a cover letter stating their motivation for the position,
their CV including education and publications, and a short description of
their experience in structural biology.

Please feel free to contact me for more information.

Phoebe Stewart
pls47 at case.edu

-- 

Phoebe L. Stewart, PhD

Professor, Department of Pharmacology

Case Comprehensive Cancer Center, Developmental Therapeutics

Cleveland Center for Membrane and Structural Biology

Case Western Reserve University School of Medicine
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