[3dem] Postdoc positions available at the University of British Columbia (Vancouver, Canada)

Thu Aug 19 16:00:24 PDT 2021

Dear colleagues,

Two postdoctoral positions are available at The University of British
Columbia in Vancouver, Canada:

*Position 1:*

 A postdoctoral position is available immediately to work on ion channel
structural biology in the lab of Filip Van Petegem, Department of
Biochemistry and Molecular Biology.

The project combines X-ray crystallography, cryo-EM, and electrophysiology.
Our lab has steady access to the in-house X-ray and cryo-EM facilities:

- Microscopes: 300kV Titan Krios with Falcon IV detector and Selectris
Energy filter.   A 200kV Glacios (Falcon III) is available for
prescreening grids.

- X-ray equipment in the lab includes Mosquito and Dragonfly robotics, and
we have regular access to an in-house X-ray diffractor (Rigaku Micromax-007
HF with Saturn 744+ CCD detector) and various synchrotron beamlines

Minimum requirement for applicants include a PhD in Biochemistry or a
related discipline with extensive experience in either X-ray
crystallography or cryo-EM, as well as protein expression and
purification.  Direct experience with membrane proteins is an additional
plus.

The lab values diversity and inclusivity, and applicants from all
background are encouraged to apply. This is an opportunity for people with
a structural biology background to learn electrophysiological methods.

Recent work from the lab includes an investigation of how Ryanodine
Receptors are modulated by small molecules, disease mutations, and
post-translational modification, using cryo-EM, X-ray crystallography,
planar lipid bilayer electrophysiology, and enzyme kinetics.

Woll et al (2021) *Nature Comm.* 12:807

Ma et al (2020) *Nat Chem Biol*. 16,1246-1254

Haji-Ghassemi et al (2019) *Molecular Cell* 75,1-14

For more information on recent work, see https://urldefense.proofpoint.com/v2/url?u=http-3A__crg.ubc.ca_VanPetegem_&d=DwIBaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=ERJtgj83MTNUjnN5PlyBqnkX0w7hf1cVaN11cRIwcaQ&s=5a-W4N_HLvvnGiD9onaBPDP3miaYbclX35aRx75SuFM&e= 

The lab is housed within the Life Sciences Centre at UBC (lsi.ubc.ca),
located on the Point Grey campus in Vancouver.

Interested candidates should send a CV, along with names and contact
details for 3 references to *filip.vanpetegem at gmail.com
<filip.vanpetegem at gmail.com>*.

--------------

*Position 2:*

An additional postdoctoral position is available to work on a joint project
between the labs of Filip Van Petegem and Robert Molday, both in the
Department of Biochemistry and Molecular Biology at the University of
British Columbia.

The project will involve Cryo-EM on neuronal membrane proteins and will
make use of the excellent cryo-EM facility within the Life Sciences
Institute.  Microscopes available include a 300kV Titan Krios with Falcon
IV detector and Selectris Energy filter.   A 200kV Glacios (Falcon III) is
available for prescreening grids. The structural biology will be
complemented with various functional assays.

The ideal candidate will have a PhD in Biochemistry or a related
discipline, as well as extensive experience with either X-ray
crystallography and/or Cryo-electron microscopy. Direct experience with
membrane protein expression and mammalian cell cultures is an additional
asset.

The Molday and Van Petegem labs are housed within the Life Sciences
Institute (https://urldefense.proofpoint.com/v2/url?u=https-3A__lsi.ubc.ca_&d=DwIBaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=ERJtgj83MTNUjnN5PlyBqnkX0w7hf1cVaN11cRIwcaQ&s=c3ADMaTzECNjep7fvFoD0fH-elbok7D4m94KXtuPhqs&e= ).

For more information on the labs, see

https://urldefense.proofpoint.com/v2/url?u=http-3A__crg.ubc.ca_VanPetegem_&d=DwIBaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=ERJtgj83MTNUjnN5PlyBqnkX0w7hf1cVaN11cRIwcaQ&s=5a-W4N_HLvvnGiD9onaBPDP3miaYbclX35aRx75SuFM&e= 

and

https://urldefense.proofpoint.com/v2/url?u=https-3A__biochem.ubc.ca_person_robert-2Dmolday_&d=DwIBaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=ERJtgj83MTNUjnN5PlyBqnkX0w7hf1cVaN11cRIwcaQ&s=IWxj01dg8-Hfj82zb4ozFVWYJlvxEWf_3TzsZIckbm8&e= 

Interested candidates should send a CV, along with names and contact
details for 3 references to both  molday at mail.ubc.ca and
filip.vanpetegem at gmail.com.

-- 
Filip Van Petegem, PhD
Professor, Dept. of Biochemistry and Molecular Biology
The University of British Columbia
2350 Health Sciences Mall - Rm 2.356
Vancouver, V6T 1Z3

phone: +1 604 827 4267
email: filip.vanpetegem at gmail.com
https://urldefense.proofpoint.com/v2/url?u=http-3A__crg.ubc.ca_VanPetegem_&d=DwIBaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=ERJtgj83MTNUjnN5PlyBqnkX0w7hf1cVaN11cRIwcaQ&s=5a-W4N_HLvvnGiD9onaBPDP3miaYbclX35aRx75SuFM&e= 

Twitter: @FilipPetegem
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