[3dem] Postdoctoral Position in development of Coherent Electron Diffractive Imaging at the Laboratory of Biological Electron Microscopy (LBEM), EPFL, Lausanne, Switzerland

[Stahlberg Henning]

We have a postdoc opening in our group LBEM at the EPFL in Lausanne, Switzerland, in the area of method development for coherent electron diffractive imaging.

The project aims to develop a system that can determine the structure of frozen hydrated proteins with a cryo-transmission electron microscope, using a high-speed hybrid pixel detector camera and diffractive imaging approaches. Proteins will be frozen in thin, free-standing ice layers as single particles, similarly as used for single particle cryo-EM. However, data will be collected with a probe Cs corrected 300kV Titan Krios cryo-EM instrument in diffraction mode, using a prototype high-speed hybrid pixel detector camera. The project involves development of data collection schemes on the electron microscope, collecting diffractive data at very high frame rates, developing and applying online pre-processing to the data, and developing structure reconstruction methods.

Candidates should have a Ph.D. in Physics, Electrical Engineering, Computer Sciences, or related disciplines, and should have expertise in electron microscopy.

The EPFL ranks among the world’s top scientific universities. It is located in Lausanne in Switzerland, a beautiful, vibrant and highly international city on the shores of scenic Lake Geneva, situated within an Alpine setting in the heart of Europe. French is the main language spoken in the city of Lausanne, while English is the main language at the EPFL and in our laboratory. The position comes with a competitive salary. EPFL is committed to being an equal opportunity employer.

The successful postdoc will join a vibrant, collaborative, international, and diverse research team with interdisciplinary expertise in biology, physics, computer science and engineering. Our lab in the Institute of Physics at the EPFL operates outstanding equipment, including a 300kV Titan Krios with Cold-FEG and Cs probe corrector, and a Talos F200C. We develop methods in cryo-EM and apply these to study neurodegeneration. In addition, the Dubochet Center for Imaging in Lausanne provides access to frontier cryo-EM, including another two Titan Krios instruments.

The position is available immediately, the start date is flexible.

Applications should include PDF documents with:
(i) Cover letter,
(ii) CV,
(iii) the contact information of three references.

For questions or additional information, please visit https://urldefense.com/v3/__https://lbem.epfl.ch__;!!Mih3wA!UTwGEkvDPYVwuzp6f2hUGua7WldANY0yZEhjfjANneHIXDiOE0o8WpDMG88BjejHuA$  or contact Henning Stahlberg at henning.stahlberg at epfl.ch .

Henning Stahlberg
Prof., Faculty of Biology and Medicine, UNIL, and
Prof. for Physics, LBEM, IPHYS, SB, EPFL
Cubotron, BSP421
CH-1015 Lausanne, Switzerland
mailto:henning.stahlberg at epfl.ch
https://urldefense.com/v3/__https://lbem.epfl.ch__;!!Mih3wA!UTwGEkvDPYVwuzp6f2hUGua7WldANY0yZEhjfjANneHIXDiOE0o8WpDMG88BjejHuA$ 

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