[3dem] Announcing major new release, EMAN2.3

Ludtke, Steven J. sludtke at bcm.edu
Fri Apr 26 07:15:54 PDT 2019


Hi all, 
a brief announcement of a new major release: EMAN2.3 (http://eman2.org), with major new features. As always, the distribution also includes SPARX (http://sparx-em.org) and the release of SPHIRE 1.2 (http://sphire.mpg.de). Releases are coordinated among the packages.

New features in EMAN2.3 include:
 * A complete CryoET pipeline from tilt series alignment through subnanometer resolution hybrid subtomogram averaging
  * fiducial-less fully automated tilt series alignment (also works with fiducials)
  * rapid tiled Fourier reconstruction
  * full tilt/geometry aware CTF correction
  * multi class 3-D particle picker with new ties to deep-learning annotation
  * SGD automatic initial model generation
  * traditional 3-D subtomogram averaging
  * per-particle per-tilt hybrid subtomogram/single particle reconstruction to subnanometer resolution

 * A new switchable filter in e2boxer making it dramatically easier to distinguish particles in images
 * New improvements to bispectral classification for 2-D unsupervised classification and 3-D refinement
 * Focused classification in 3-D refinement available from the workflow interface
 * Improvements to e2extractsubparticles as an alternative to focused classification
 * Upgrade from Qt4 to Qt5 as part of the process of transitioning to Python3 over the next year 
 * Many minor bugfixes

--------------------------------------------------------------------------------------
Steven Ludtke, Ph.D. <sludtke at bcm.edu>                      Baylor College of Medicine 
Charles C. Bell Jr., Professor of Structural Biology
Dept. of Biochemistry and Molecular Biology                      (www.bcm.edu/biochem)
Academic Director, CryoEM Core                                        (cryoem.bcm.edu)
Co-Director CIBR Center                                    (www.bcm.edu/research/cibr)





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