[3dem] Cryo-EM Post-Doctoral Opportunities in New York

[Anthony Fitzpatrick]

The Fitzpatrick lab, a member of the Zuckerman Mind Brain Behavior
Institute at Columbia University, has 5 openings for postdoctoral research
associates funded by a recent NIH U01 award to study the structural biology
of tau and TDP-43 in neurodegenerative diseases.

Situated in the heart of Manhattan, the Zuckerman Institute houses sixty
laboratories employing a broad range of interdisciplinary approaches to
transform our understanding of the mind and brain. In this highly
collaborative environment, labs work together to gain critical insights
into human health by exploring how the brain develops, performs, endures
and recovers from trauma or disease.

In our lab, we leverage the latest developments in cryo-electron microscopy
with complementary biophysical techniques (proteomics, light-microscopy,
microfluidics) to explore the molecular basis of neurodegeneration (e.g.
PNAS 110, 5468-5473 and Nature 547, 185-190). To this end, we determine the
structure and function of protein complexes, purified directly from
postmortem brain tissue, that are implicated in a range of
neurodegenerative diseases. Additionally, we will visualize the behavior of
these complexes within the cellular context using light-microscopy and
cryo-electron tomography.

Members of the lab will have access to a state-of-the-art suite of electron
microscopes:

4 FEI Titan Krios microscopes with Gatan BioQuantum energy filter and K3
Summit direct electron detector

FEI Polara F30 with Gatan K3 Summit direct electron detector

FEI F20 with Gatan K2 Summit direct electron detector

FEI Glacios with Falcon 3 direct electron detector

FEI Helios 650 SEM/FIB (New York Structural Biology Center)

We are looking for outstanding scientists who have a strong background in
biophysics, biochemistry or neuroscience, and are highly motivated to learn
single-particle cryo-EM. Prior experience with single-particle cryo-EM or
X-ray crystallography is considered an advantage, but is not essential.

If you’re interested in joining our lab, please send your CV with a brief
description of your current research, as well as 2-3 contacts for
references, to anthony.fitzpatrick at columbia.edu.

Columbia University is an Affirmative Action/Equal Opportunity employer.
Columbia values diversity among its students, staff, and faculty and
strongly welcomes applications from women, persons with disabilities,
protected veterans, and underrepresented minorities.

########################################################################
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://mail.ncmir.ucsd.edu/pipermail/3dem/attachments/20181015/d3ae13f3/attachment.html>