[3dem] THE EIGHTH BRAZIL SCHOOL FOR SINGLE PARTICLE CRYO-EM (second announcement)

[Marin van Heel]

Second Announcement

THE EIGHTH BRAZIL SCHOOL FOR SINGLE PARTICLE CRYO-EM.

27 Sept - 9 Oct 2018, Maripora, SP Brazil  ( www . brazil-school . org )

Our single-particle school is a unique and intensive 12-day hands-on 
course/workshop, in which theory and practice are tightly intertwined. 
The understanding of the principles of cryo-EM data processing stands 
central in this event and a few cryo-EM pioneers will explain the 
approaches to the participants to a level where they can apply it 
themselves. The spectrum of topics covered suits attendees who are new 
to the field as well as those for whom the technique is of growing 
importance and who wish to acquire an in-depth understanding of the 
fundamental principles.  The final days of the meeting will be devoted 
to advanced topics such as high-resolution refinements and the 
processing of heterogeneous data sets ("4D cryo–EM”). Advanced topics 
will include:

1)    Optimizing data collection with direct electrons detectors and 
exploiting movies.
2)    Full data set automatic CTF correction.
3)    Correction of anisotropic magnification.
4)    Reaching atomic resolution without reference bias: 
alignment-by-classification (ABC-4D) refinement procedures.
5)    Unbiased "Random Startup" of 3D and 4D reconstructions.
6)    4D refinement procedures for high-resolution results using IMAGIC, 
Frealign/cisTEM and Relion.
7)    Fitting and refining atomic coordinates in high-resolution cryo-EM 
maps (~4Å or better) using programs such as REFMAC and Coot.
8)    Validation and interpretation of final results using reproducible 
resolution metrics.

Marin van Heel

Note: Whereas the final deadline for applications is the 1st of June 
2018, we will already accept the first 20 attendees – half of the 
available places – among those who have registered before the end of 
this week (the lab is closed until Wednesday). The results of this first 
selection will be announced by the 14th/15th of May. This will allow 
more time for those who need to apply for funding separately .

==============================================================

     Prof Dr Ir Marin van Heel

     Laboratório Nacional de Nanotecnologia - LNNano
     CNPEM/LNNano, Campinas, Brazil
     email:  marin.vanheel(A_T)gmail.com
                 marin.vanheel(A_T)lnnano.cnpem.br
     and:    mvh.office(A_T)gmail.com
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     Emeritus Professor of Cryo-EM Data Processing,    Leiden University
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     Emeritus Professor of Structural Biology,    Imperial College London
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