[3dem] iNEXT Integrated Access "EM Bundle" Call (deadline: April 20th, 2018)

[Slavica Jonic]

Dear All,

I would like to attract your attention to the currently open Integrated
Access "EM Bundle" Call of iNEXT (https://www.structuralbiology.eu/submit-
proposal/step1/new), with the deadline on April 20th, 2018. The researchers
from all EU and associated countries can apply, but international labs are
also eligible (in a more limited capacity).

iNEXT is a European program that supports access to research
infrastructures for Structural Biology. The “EM Bundle" should help
researchers carry a project from the sample to the initial structure
determination by EM.

The proposal (less than one thousand words) should describe the background
of the project in the lab, the general scientific background, and the value
for translational research (biomedical or biotechnological application). No
prior experience in EM is required.

For more information, please see below.Please forward this information
to your colleagues who might be less familiar with structural biology
but potentially interested.

Best regards, Slavica



*Subject:*

iNEXT EM and X-ray bundles!
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Dear all,

iNEXT, a European program to support access to research
infrastructures for Structural Biology, is now welcoming applications
for the “EM and X-ray bundles", to help people carry a project all the
way from the starting sample to the initial structure determination,
by EM or X-rays.

To apply for either bundle you need exciting translational research
projects, for which you have the macromolecule or complex you want to
study in purified soluble form, and you want to engage in structural
studies. In a short application form (less than one thousand words
overall), you will need to describe the background of the project in
your lab and current results, the general scientific background, and
the value for translational research (short term but also long term
value in any short of biomedical or biotechnological application). No
prior experience on either method is required.

For the EM bundle, projects will start with an initial
characterisation for optimal stability conditions, molecular weight in
solution, and negative stain EM (if you send enough sample, we can
also try to crystallise it if you wish - just in case!). At this stage
you will only need to send the sample to us. Projects that look most
promising after that first step, will proceed to optimising the
cryo-conditions in one of the iNEXT EM facilities, with your
participation. Finally, projects that do best in cryo-optimisation,
will proceed to collect data in one of the high-end microscopes
available to iNEXT.

For the X-ray bundle, projects will start with an initial
characterisation for optimal stability conditions, molecular weight in
solution, and crystallisation trials. Projects that either yield
crystals, or promising precipitates, will proceed to extensive
crystallisation trials. For all projects that will yield crystals
diffraction data will be collected in one of the fully automated X-ray
facilities that collaborate in iNEXT. You will only need to send the
sample to us and in most cases physical presence will not be required.

It should be emphasised, that no re-application will be needed at any
step and iNEXT will cover all experimental expenses, and contribute to
travel costs, when needed.

There is a single deadline on Friday 20th April 2018.

You can Submit a Proposal by clicking
here<https://www.structuralbiology.eu/submit-proposal/?t=inext> or go
to the iNEXT web site: http://www.inext-eu.org and follow the “Submit
Proposal” link.

Please note, that given the iNEXT resources availability, this is
likely the only call for these “bundle” access. These will serve as
pilots for likely requesting future funding from the EU, if such an
opportunity becomes available.

We note that researchers from all EU and associated countries can
apply, but also international labs are eligible, albeit in a more
limited capacity.

Please forward this email beyond this bulletin list, especially to
colleagues that might be less familiar with structural biology.
Consider asking this colleague of yous that wanted to do a structural
biology project and you never had time or the resources to try hers or
his exciting idea! Preliminary results from this bundle access, or a
structure, can be the basis for your next grant application!

Please also keep in mind that iNEXT remains open to all kinds of
Structural Audit, Enhanced Support, and High-End data collection, for
projects that involve X-ray Crystallography, SAXS, solution and solid
state NMR, EM single particles, EM tomography or CLEM, biophysics for
looking at macromolecular interactions, advanced light imaging, and
ligand and fragment screening! All these access modalities are listed
on our web site!

Best regards and looking forward receiving your project,

The iNEXT coordination and management team and all iNEXT partners



-- 
Dr Slavica JONIC
CNRS Associate Scientist

IMPMC-CNRS UMR 7590
Sorbonne Université
Case courrier 115
4 Place Jussieu
75005 Paris, France

Tel: +33 1 44 27 72 05
Fax: +33 1 44 27 37 85

E-mail: Slavica.Jonic at upmc.fr
URL: http://www.impmc.upmc.fr/~jonic
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