[3dem] Announcing the release of EMAN2.2

[Ludtke, Steven J]

We are pleased to announce the release of EMAN 2.2 (distributed jointly with SPHIRE/SPARX). This new version has been a long time coming and has a very long list of improvements.

For details and downloads, please see:

http://eman2.org

A few of the more interesting improvements since the 2.12 release (full release notes http://eman2.org/Eman22Release) :

Single Particle
- Many refinement changes and new filtering techniques (side-chains look better than Relion or CryoSparc in some cases)
- New bad particle identification strategy, demonstrated to produce better maps
- Local map resolution and filtration
- New automated CTF pipeline  permits very easy(and fast) progressive resolution refinement within a single project folder
- Several new tools for flexibility/dynamics analysis
- New particle picking program (with neural net picker for difficult cases)
- Stochastic Gradient Descent initial model generator (experimental)
- Automatic magnification anisotropy correction tool
- New direct detector movie alignment (experimental)
- New 2-D registration algorithm, faster and more accurate for large box-sizes

Tomography/Subtomogram Averaging
- New subtomogram averaging tools, including up to 20x faster 3-D alignments
- Neural net-based semi-automatic tomogram segmentation (GPU enabled)

General
- New Anaconda Python based distribution with integrated SciPy and other Python libraries
- Source now managed/available through GitHub
- For the first time we have some support for Win10/7 64 bit (not yet well tested, but feel free to try it)

Please see the Google Group for ongoing discussions: http://groups.google.com/group/eman2
or email me directly at any time

Cheers

----------------------------------------------------------------------------
Steven Ludtke, Ph.D.
Professor, Dept of Biochemistry and Mol. Biol.         (www.bcm.edu/biochem)
Co-Director National Center For Macromolecular Imaging        (ncmi.bcm.edu)
Co-Director CIBR Center                          (www.bcm.edu/research/cibr)
Baylor College of Medicine                             
sludtke at bcm.edu