[3dem] Industrial cryo-EM position: Cryo-EM at Pfizer (Groton, CT)

Han, Seungil seungil.han at pfizer.com
Tue Nov 15 08:34:06 PST 2016


Pfizer Structural Biology group (Groton, CT) has an opening for Senior Scientist, cryo-EM (Job ID: 1042357) and the candidate can apply the job in the link below.

Thanks in advance for your interest!

Seungil Han


Senior Scientist - Cryo-EM

Job ID: 1042357

Location: United States-Connecticut-Groton Role Description

The successful candidate will join the department of Groton Structural Biology and Biophysics (SB&B), a multidisciplinary group with established expertise in molecular biology, protein biochemistry, biological mass spectrometry, proteomics, enzymology, NMR, biophysics and crystallography. Our mission is to provide integrated molecular insights into drug target mechanism and target-ligand interactions to promote discovery efforts across multiple therapeutic areas, including Inflammation and Immunology, Neuroscience, Cardiovascular, Metabolic & Endocrine Diseases, Pain, Rare Diseases and Oncology.

Within Pfizer, we have made a strong commitment to invest in single particle cryo-EM and have set up a state of the art microscope (Titan Krios) with a K2 direct electron detector in newly renovated laboratory, a dedicated CPU/GPU computer cluster and a TF20 microscope for screening samples.

As a Senior Scientist, you will have experience with all aspects of structure determination by cryo-EM technology including sample preparation, data collection, data processing using state-of-art software, and 3-D reconstruction. Ideally you will also be familiar with the hardware associated with EM data collection such as microscope, direct electron detector, sample robot etc. and their maintenance. Equally important will be your ability to collaborate successfully with other scientists in the department and with biologists and chemists in multiple drug discovery teams. You will eventually be expected to understand the critical issues and challenges faced by different drug discovery programs within Pfizer and design suitable experimental strategies based on cryo-EM technique that could positively impact the outcomes.


The Senior Scientist will design and perform experiments in the technical area of single particle cryo-EM.

Experimental results will be formulated computationally and will be recorded in an electronic laboratory notebook.

Prompt and clear communication will occur with project team colleagues.

External scientific publication and presentation will be encouraged when appropriate as a means of assuring optimal research standards.


Doctoral degree or equivalent in Biochemistry, Biophysics, Physics, Chemistry or related field.

* Postdoctoral training in cryo-EM with ca. 2-5 years of academic or relevant industrial experience.

* Broad knowledge of biology and molecular techniques in protein science and chemistry are also desirable.

* Proven ability to design and conduct state-of-the-art single particle cryo-EM experiments, leading to a strong track record of successful outcomes with publications in leading journals. Has the skill and drive to grow into a thought leader in this field.

* Familiar with protein characterization, biophysical, structural and computational techniques to facilitate problem-solving.
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