[3dem] Two open positions: Cryo-EM at Pfizer (Groton, CT)

[Han, Seungil]

All,
Pfizer Structural Biology group (Groton, CT) has two openings for cryo-EM (Job ID: 1029501 and 1029509) and the candidate can apply the job in the link below.
Thanks in advance for your interest!
Seungil Han


www.pfizercareers.com<http://www.pfizercareers.com>

Senior Scientist - Cryo-EM
Job ID: 1029501
Location: United States-Connecticut-Groton
Role Description

The successful candidate will join the department of Groton Structural Biology and Biophysics (SB&B), a multidisciplinary group with established expertise in molecular biology, protein biochemistry, biological mass spectrometry, proteomics, enzymology, NMR, biophysics and crystallography. Our mission is to provide integrated molecular insights into drug target mechanism and target-ligand interactions to promote discovery efforts across multiple therapeutic areas, including Inflammation and Immunology, Neuroscience, Cardiovascular, Metabolic & Endocrine Diseases, Pain, Rare Diseases and Oncology.

Within Pfizer, we have made a strong commitment to invest in single particle cryo-EM and have set up a state of the art microscope (Titan Krios) with a K2 direct electron detector in newly renovated laboratory, a dedicated computer cluster and a TF20 microscope for screening samples.

As a Senior Scientist, you will have experience with all aspects of structure determination by cryo-EM technology including sample preparation, data collection, data processing using state-of-art software, and 3-D reconstruction. Ideally you will also be familiar with the hardware associated with EM data collection such as microscope, direct electron detector, sample robot etc. and their maintenance. Equally important will be your ability to collaborate successfully with other scientists in the department and with biologists and chemists in multiple drug discovery teams. You will eventually be expected to understand the critical issues and challenges faced by different drug discovery programs within Pfizer and design suitable experimental strategies based on cryo-EM technique that could positively impact the outcomes. SB&B is part of Worldwide Medicinal Chemistry group within Pfizer, with the overall goal of understanding the mode of action of lead compound using an integrated assessment of all aspects of protein-ligand interactions to drive drug discovery efforts.

Responsibilities

The Senior Scientist will design and perform experiments in the technical area of single particle cryo-EM.
Experimental results will be formulated computationally and will be recorded in an electronic laboratory notebook.
Prompt and clear communication will occur with project team colleagues.
External scientific publication and presentation will be encouraged when appropriate as a means of assuring optimal research standards.

Qualifications

Doctoral degree or equivalent in Biochemistry, Biophysics, Physics, Chemistry or related field.
* Postdoctoral training in cryo-EM with ca. 2-5 years of academic or relevant industrial experience.
* Broad knowledge of biology and molecular techniques in protein science and chemistry are also desirable.
* Proven ability to design and conduct state-of-the-art single particle cryo-EM experiments, leading to a strong track record of successful outcomes with publications in leading journals. Has the skill and drive to grow into a thought leader in this field.
* Familiar with protein characterization, biophysical, structural and computational techniques to facilitate problem-solving.

Senior Scientist - Membrane Protein for Cryo-EM
Job ID: 1029509
Location: United States-Connecticut-Groton
Role Description

The successful candidate will join the department of Groton Structural Biology and Biophysics (SB&B), a multidisciplinary group with established expertise in molecular biology, protein biochemistry, biological mass spectrometry, proteomics, enzymology, NMR, biophysics and crystallography. Our mission is to provide integrated molecular insights into drug target mechanism and target-ligand interactions to promote discovery efforts across multiple therapeutic areas, including Inflammation and Immunology, Neuroscience, Cardiovascular, Metabolic & Endocrine Diseases, Pain, Rare Diseases and Oncology.

Within Pfizer, we have made a strong commitment to invest in single particle cryo-EM and have set up a state of the art microscope (Titan Krios) with a K2 direct electron detector in newly renovated laboratory, a dedicated computer cluster and a TF20 microscope for screening samples.

As a Senior Scientist, you will have experience with structure determination by cryo-EM technology including sample preparation, data collection, data processing using state-of-art software, and 3-D reconstruction. Ideally you will also be familiar with protein construct design, molecular biology and mutagenesis, protein expression, purification and biochemical/biophysical characterization of a membrane protein.

Equally important will be your ability to collaborate successfully with other scientists in the department and with biologists and chemists in multiple drug discovery teams. You will eventually be expected to understand the critical issues and challenges faced by different drug discovery programs within Pfizer and design suitable experimental strategies based on cryo-EM technique that could positively impact the outcomes. SB&B is part of Worldwide Medicinal Chemistry group within Pfizer, with the overall goal of understanding the mode of action of lead compound using an integrated assessment of all aspects of protein-ligand interactions to drive drug discovery efforts.

Responsibilities

* The Senior Scientist will design and perform experiments in the technical area of membrane protein purification, characterization and involved in single particle cryo-EM.
* Experimental results will be formulated computationally and will be recorded in an electronic laboratory notebook.
* Prompt and clear communication will occur with project team colleagues.
* External scientific publication and presentation will be encouraged when appropriate as a means of assuring optimal research standards.

Qualifications
* You should have a PhD or be a PhD candidate (to be completed in 2016) in Biochemistry, Biophysics, Physics, Chemistry or a related field.
* You should have the desire and experience to carry out single particle cryo-EM work with suitable independence, and have the creativity and drive to tackle scientific challenges.
* Membrane protein purification experience is required.
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://mail.ncmir.ucsd.edu/pipermail/3dem/attachments/20160322/45fb0c46/attachment.html>