[3dem] Postdoctoral Position in Wright Lab

[Wright, Elizabeth R.]

Postdoctoral Position In Wright Lab (Emory University)

An NIH-funded postdoctoral position to study paramyxovirus assembly is available in my lab (http://electronmicroscopy.emory.edu<http://electronmicroscopy.emory.edu/>). Major research efforts in the lab are focused on bacterial and viral structural biology, with emphasis on 3-D structure/function relationships between host cells and viruses. Areas of particular interest include cryo-electron tomography of bacteria, bacteria - bacteriophage interactions, paramyxoviruses, and HIV-1. Technology development interests are in the areas of correlative microscopy and phase plate cryo-microscopy.

Publications applicable to the projects associated with the position:
G. Kiss, J. M. Holl, G. M. Williams, E. Alonas, D. Vanover, A. W. Lifland, M. Gudheti, R. C. Guerrero-Ferreira, V. Nair, H. Yi, B. S. Graham, P. J. Santangelo, and E. R. Wright. "Structural Analysis of Respiratory Syncytial Virus Reveals the Position of M2-1 Between the Matrix Protein and the Ribonucleoprotein Complex." Journal of Virology. 2014: 88 (13): 7602-7614.

H. Yi, J. D. Strauss, Z. Ke, E. Alonas, R. S. Dillard, C. M. Hampton, K. M. Lamb, J. E. Hammonds, P. J. Santangelo, P. W. Spearman and E. R. Wright. "Native Immunogold Labeling of Cell Surface Proteins and Viral Glycoproteins for Cryo-Electron Microscopy and Cryo-Electron Tomography Applications." Journal of Histochemistry and Cytochemistry. 2015: 63 (10): 780-792.

J. D. Strauss, J. E. Hammonds, H. Yi, L. Ding, P. W. Spearman, and E. R. Wright.  "Three-Dimensional Structural Characterization of HIV-1 Tethered to Human Cells." Journal of Virology. 2016: 90 (3): 1507-1521.

The wet laboratory is within the Division of Pediatric Infectious Diseases and is fully equipped for all aspects of microbiology, molecular biology, molecular virology, and protein biochemistry. The Wright lab is equipped with a JEOL JEM-2200FS 200 kV FEG TEM with an in-column energy filter, phase plate system, Direct Electron DE-20 direct electron detector, and Gatan 4kx4k CCD camera. For cryo-CLEM development and experiments, a Leica cryo-CLEM system has recently been installed. The laboratory also has an FEI Vitrobot, a Gatan CP3 and a manual grid plunge freezer; a Leica cryo-ultramicrotome; an Improvision spinning disk confocal microscope; and a Zeiss TIRF microscope. The group has access to all the resources available in the Emory University EM Core Facility, to include: a JEOL JEM-1400 120 kV TEM with Gatan 2kx2k CCD camera; a Bal-Tec high-pressure freezer; and Leica freeze substitution system.

Candidates should have an interest in structural biology and virology; excellent communication skills; and enjoy working as part of a dynamic and collaborative research team. Background experience in one (or more) of the following fields is desirable: molecular biology, virology, (cryo-) electron microscopy, protein crystallography, and/or image processing/analysis techniques.

Applicants should include a cover letter describing research experience and interests, curriculum vitae, and names and contact information for three references.

 --
Elizabeth R. Wright, PhD
Assistant Professor
Emory University
erwrigh at emory.edu
(404) 727-4665


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