[3dem] Post-doctoral position in Amsterdam

t.sixma at nki.nl t.sixma at nki.nl
Tue Apr 19 22:33:35 PDT 2016


A post-doctoral position is available in the Netherlands Cancer Institute in the group of Titia Sixma. We are searching for a candidate with expertise in cryo-electron microscopy single particle reconstruction.

The group has a long-standing interest in structural studies coupled to functional analysis and is currently making the transition to using cryo-EM in addition to ongoing X-ray crystallography and NMR projects. Several biochemically stable and well‑characterized protein complexes are currently waiting for structure determination. We have excellent access to high-end microscopy (NeCEN); testing microscopes are available and the computational infrastructure is setup and ready to go, including access to the Dutch supercomputer Cartesius.

Topics of the projects center around the role of ubiquitin conjugation in DNA repair and epigenetic regulation. Integration with biology groups studying these themes is excellent, thanks to close proximity of high class science on site and close by.

The Netherlands Cancer Institute is a center of excellence with a high standard of biological research and an interactive atmosphere. It is located in Amsterdam, with all its cultural amenities, and is close to Schiphol airport.

We share meetings and lab-space with the group of Tassos Perrakis, who amongst other things has an interest in method development for structural biology. Equipment includes high throughput crystallization, routine synchrotron access, and excellent biophysics (SPR, stopped-flow, ITC, thermophoresis, MALLS, Optim etc).

We are looking for an enthusiastic researcher with expertise in cryo-EM sample preparation and electron microscopy. Applicants should write an e-mail with CV and names of three references to t.sixma at nki.nl<mailto:t.sixma at nki.nl>.

Titia K. Sixma
Netherlands Cancer Institute
Plesmanlaan 121
1066 CX Amsterdam
t.sixma at nki.nl<mailto:t.sixma at nki.nl>
Tel : +31205121959



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