[3dem] problematic paper about gold nano particle labeling just published in Structure

Masahide Kikkawa mkikkawa at m.u-tokyo.ac.jp
Sun Jun 22 17:27:16 PDT 2014

One more vote for the fraud:
Figure 3B
 The third image is rotated CW and overlaid on the second image. 
 Seems the magnifications of the two images are slightly different.

Besides this, enjoy 3DEM Gordon!

Masahide Kikkawa, M.D., Ph. D.
Department of Cell Biology & Anatomy
Graduate School of Medicine
The University of Tokyo
tel: +81-3-5841-3338
fax: +81-3-5841-3339

On Jun 11, 2014, at 10:25 AM, Jensen, Grant J. <jensen at caltech.edu> wrote:

> Dear colleagues,
> bad news: a post-doc in my lab called my attention to a figure in a paper published recently in Structure that appears to be fraudulent.  
> It is Figure 3 of 
> High-Affinity Gold Nanoparticle Pin to Label and Localize Histidine-Tagged Protein in Macromolecular Assemblies
> Kelsey C. Anthony, Changjiang You, Jacob Piehler, Daniel A. Pomeranz Krummel
> Structure, Vol. 22, Issue 4, p628–635
> Published online: February 20, 2014
> It appears that parts of one image have been duplicated and cut and pasted into other images, with “gold” particles added (photoshopped?) on top.  If you’d like to judge for yourself, please see the two slides I’ve attached.  Note how the background noise spots marked with the black arrows match, as do the noise spots marked with the red arrows, and note the strange square box around the particle marked with the blue arrow.  In the bottom, I have captured a screen shot of the particle marked with my star on the upper left corner and cut and paste it next to the two particles supposedly “decorated” with gold fiducials on the right, but notice how all three particles seem to be identical.  Even the noise around the particles match.
> We alerted the journal editors a few weeks ago, but as it now appears that their process to deal with this could be long, we wanted to alert the community too before anyone lost time pondering this new “method”.  
> Grant

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