[3dem] Postdoctoral position in Birkbeck College, single particles

Elena Orlova e.orlova at mail.cryst.bbk.ac.uk
Thu May 24 13:50:10 PDT 2012

Dear colleagues


We are seeking a motivated Postdoctoral Research Assistant to carry out structural biology research on the helicase complex E1
  and its complexes with DNA in the lab of Prof. Elena Orlova  (Institute for Structural and Molecular Biology, Department of Biological
Sciences, Birkbeck College). This study will be done in collaboration with Dr. C. Sanders (University of Sheffield).

Helicases are an important class of enzyme and they are therapeutic 
targets in cancer and viral diseases. They remain poorly
understood. The work will advance our understanding of the mechanisms of 
DNA replication in a well-recognized and established
  model organism.  We propose to employ advanced cryo-electron 
microscopy, statistical analysis and image processing to obtain
3D structures of the initiator protein E1-DNA complex in bovine 
papillomavirus. The Institute of Structural and Molecular Biology
of London (ISMB) and the Department of Biological Sciences at Birkbeck 
(BS) form the focal point for structural research and
  encourages collaborations with chemists and computational biologists. 
BS/ISMB is an international centre for EM studies housing
Tecnai 10, 12, FEGF20 andFEG Polara microscopes (FEI) equipped with CCD 
cameras allowing efficient data collection.All
necessary techniques and expertise required for the successful execution 
of the project are in place, we are using a combination
of different software packages (SPIDER, EMAN, IMAGIC, and other) for 
image analysis, utilizing the most efficient features of
  each system to provide the best results.


PhD (or equivalent) in a relevant subject area required. Experience of 
multi-protein complex expression and purification,
single particle electron microscopy will be an advantage.

*Closing date -- June 17th, 2012*

Please apply online via our website 
<http://www3.imperial.ac.uk/employment> (please select "Postdoctoral
Researcher, Biological Sciences", *Reference Number**10748*.  Click on 
the line "Click here to apply for this job 
, Go to "Apply
  now" . Please complete and upload an application form as directed, 
attaching a curriculum vitae, a cover letter and the name
and contact details of two referees. Informal enquiries should be made 
to Prof. Elena Orlova, Department of
Biological Sciences email: e. orlova at mail.cryst.bbk.ac.uk 
<mailto:e.%20orlova at mail.cryst.bbk.ac.uk> telephone: + 44 (0)20 7631 
6845 (http://people.cryst.bbk.ac.uk/~ubcg55a/ 

Alternatively, if you are unable to apply online, please contact Geoff 
Rideout (g.rideout at mail.cryst.bbk.ac.uk 
<mailto:g.rideout at mail.cryst.bbk.ac.uk>) by email to request an 
application form.


Prof. Elena Orlova
Crystallography, Institute for Structural and Molecular Biology,
Department of Biological Sciences
Birkbeck,  University of London,
Malet Street,
Tel: (+44) (0)20 7631 6845
Fax: (+44) (0)20 7631 6803
e-mail: e.orlova at mail.cryst.bbk.ac.uk

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