Meeting announcement, last call

andreas hoenger hoenger at
Mon Feb 9 01:51:36 PST 2004

Dear Colleagues

Please have a look at the following Meeting Announcement.
The application deadline will be by the end of this week. A list
of already registred and accepted participants is now available
on the web.

Best wishes,		Andy Hoenger


International Workshop on:


March 17-20, 2004
Granlibakken Conference Center, Lake Tahoe, CA.

Information and online-registration at:

limited to 120 attendees, registration fee $80.-

The Symposium will consist of six platform sessions and two
poster sessions.

Selected Talks: In addition to invited talks, talks will be selected
from submitted abstracts. There will be 10-12 of the latter talks i.e.
1-2 per platform session.

Attendance. The intention is to bring together a diverse group of
scientists who are interested in hybrid approaches. Attendance is
limited to 120. Applicants are encouraged to present their research.
Applications will be processed expeditiously upon receipt, so early
application is encouraged.

Sessions on:
Proteomics of Macromolecular Complexes
(Chair: W. Baumeister, MPI-Martinsried, Germany, DE)

Hybrid Approaches to Macromolecular Machines
(Chair: P. Bjorkman, Caltech, Pasadena, CA)

Hybrid Approaches to Filament Structure
(Chair: U. Aebi, Biocenter, Univ. of Basel, CH)

Hybrid Approaches to large Dynamic Assemblies
(Chair: A. Steven, NIAMS-NIH, Bethesda, MD)

Hybrid Approaches to Cellular Structures
(Chair: J. R. McIntosh, Univ. of Colorado, Boulder, CO)

Computational Methods in Hybrid Structures
(Chair: J.E. Johnson, TSRI, La Jolla, CA)

Rachel Santarella, EMBL-Heidelberg, 69117, Heidelberg DE
Tel: +49 6221 387 362, Fax: +49 6221 387 519
Email: emhybrid at

Goals: In recent years, it has become increasingly apparent that the key
level in the structural hierarchy for most fundamental biological
processes is not the single protein subunit nor the membrane-bound
organelle but the supramolecular assembly. Assemblies, or machines as
many of them are designated, are typically composed of many subunits,
with molecular weights running into the millions of Daltons. Moreover,
machines are dynamic entities whose transitions may include the shedding
of some subunits, the recruitment of others, and the binding and release
of substrates to the accompaniment of local and global conformational
changes. Understanding biology at this level requires elucidation of
their ground state structures, as well as each alternative
conformation. Individually, the traditional branches of structural
biology have only a limited capability to tackle this challenge. In
these circumstances, hybrid methods combining X-ray crystallography,
cryo-electron microscopy, NMR spectroscopy, computational biology and
other innovative approaches are essential. The goal of this Workshop is
to illustrate the power of hybrid methods; evaluate their strengths and
weaknesses as currently practiced; and to delineate promising future

Andreas Hoenger Ph.D.
European Molecular Biology Lab
Structure Programme
Meyerhofstrasse 1, 69117 HEIDELBERG, Germany

Tel: +49 6221 387 453;    Fax: +49 6221 387 519 or 306
Email: Hoenger at

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