Postdoctoral fellow needed

[Mona Norcum]

A postdoctoral fellow is needed for structural analysis of the eukaryotyic multienzyme complex of aminoacyl-tRNA synthetases.  The project focus is to test and refine the three domain model of the multisynthetase complex by calculation of its three-dimensional structure from cryoelectron microscopic images and by mapping locations of its constituent polypeptides using labeled tRNAs and antibodies as structural probes.   

A starting date of April - May 2001 is ideal, but later dates will be considered, if necessary.  The position will be funded for at least 3 years by NSF.  

Required experience:
    Ph.D. in Biochemistry/Biophysics/Biology with specialization in computational microscopy.
    Specific skills must include:  acquisition of cryoelectron microscopic data and calculation of three-dimensional volumes using single particle methods in SGI IRIX environment (SPIDER/WEB and EMAN packages are currently available)
     Other desired skills:  basic biochemical methodology including protein and nucleic acid purification and labeling, HPLC operation

Pertinent equipment:
     Three year old LEO 912AB energy filtered microscope 
      Oxford cryoholder and LEO cryobox for preparing specimens
      SGI Octane computers with connection to 64 processor SGI Origin

For more information:
     Please contact me and/or visit the department web site:                                                  http://www2.umsmed.edu/dept/biochemistry
     Recent laboratory projects and publications can be found at:    
         http://www2.umsmed.edu/dept/biochemistry/norcum.html 

Application process:
     Please send letter of application, CV and list of 3 references by mail, FAX or email to:
       Professor Mona T Norcum
       Biochemistry Department
       University of Mississippi Medical Center
       2500 North State Street
      Jackson, MS 39216-4505 USA
      Phone: 601-984-1527  FAX: 601-984-1501
      email: mnorcum at biochem.umsmed.edu 



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